Fujishiro K, Imazu K, Makita Y, Inoue N
Occupational Health Training Center, University of Occupational and Environmental Health, Kitakyushu.
Fukuoka Igaku Zasshi. 1994 Aug;85(8):247-50.
The toxicity of dichloropropanols (DCPs) was investigated by hematological and blood chemical examination. Solutions of two isomers of DCPs, 1,3-dichloro-2-propanol (DC2P) and 2,3-dichloro-1-propanol (DC1P) were dissolved in saline at a concentration of 100 mg/ml and 0.1 ml of each was subcutaneously injected into male Wistar rats weighing about 200 g. Acute changes on transaminases and number of platelets were determined in the time course. 6 hours later, transaminases showed significant increases while the number of platelets significantly decreased in the DC2P-treated group. In the half the of DC2P-treated group, transaminases had increased furthermore at 24 hours, while those in the rest were recovered to the control level. No changes were observed in the DC1P-treated group. These results indicate that there is a prominent hepatotoxicity in DC2P, with the individual diversities to some extent and the hepatic toxicity differs considerably between DC2P and DC1P. Therefore, the monitoring of the working environment and biological monitoring of DCPs should be mandatory, in the workplace where DCPs, especially DC2P, are utilized.
通过血液学和血液化学检查研究了二氯丙醇（DCPs）的毒性。将两种DCPs异构体，即1,3 - 二氯 - 2 - 丙醇（DC2P）和2,3 - 二氯 - 1 - 丙醇（DC1P）的溶液以100 mg/ml的浓度溶解于生理盐水中，分别取0.1 ml皮下注射到体重约200 g的雄性Wistar大鼠体内。在时间进程中测定转氨酶和血小板数量的急性变化。6小时后，DC2P处理组的转氨酶显著升高，而血小板数量显著减少。在DC2P处理组的一半大鼠中，24小时时转氨酶进一步升高，而其余大鼠的转氨酶恢复到对照水平。DC1P处理组未观察到变化。这些结果表明，DC2P具有显著的肝毒性，存在一定程度的个体差异，且DC2P和DC1P的肝毒性有很大差异。因此，在使用DCPs，尤其是DC2P的工作场所，对工作环境的监测和DCPs的生物监测应成为强制性要求。
