Van den Driessche J, Linée P, Le Pollès J B, Lacroix P
C R Seances Soc Biol Fil. 1978;172(2):325-9.
In curarized rats, acute and iterative asphyxic anoxia produced large modifications of the cerebral electrogenesis, whose intensity could be evaluated, during each anoxia, by measurements of three parameters : the resistance to anoxia, the post-asphyxic recuperation and the cerebral electric silence. Comparative trials, carried out on animals of the same stock, showed that the cerebral sensibility towards anoxia was very different according to their age : maximal sensibility in 2 or 28 months old rats, minimal sensibility between 8 to 15 months. These results are discussed in terms of choice of animal material and specially of the age of rats used for study of the cerebral anoxia, as well as for the study of cerebral anti- hypoxic drugs.
在使用箭毒的大鼠中，急性和反复的窒息性缺氧会使大脑电发生产生很大改变，每次缺氧时其强度可通过测量三个参数来评估：对缺氧的耐受性、窒息后恢复情况以及大脑电静息。对同一品系动物进行的对比试验表明，根据年龄不同，大脑对缺氧的敏感性差异很大：2个月或28个月大的大鼠敏感性最高，8至15个月大的大鼠敏感性最低。本文就动物材料的选择，特别是用于研究大脑缺氧以及大脑抗缺氧药物的大鼠年龄，对这些结果进行了讨论。
