Stepankova Katerina, Fenton André A, Pastalkova Eva, Kalina Miroslav, Bohbot Véronique D
Department of Neurology, Hospital Na Homolce, Roentgenova 2, Prague 5 151 19, Czech Republic.
Neuropsychologia. 2004;42(8):1017-28. doi: 10.1016/j.neuropsychologia.2004.01.002.
Memory for object-location was investigated by testing subjects with small unilateral thermolesions to the medial temporal lobe using small-scale 2D (Abstract) or large-scale 3D (Real) recall conditions. Four patients with lesions of the left hippocampus (LH), 10 patients with damage to the right hippocampus (RH) and 9 matched normal controls (NC) were tested. Six task levels were presented in a pseudorandom order. During each level, subjects viewed one to six different objects on the floor of a circular curtained arena 2.90 m in diameter for 10 s. Recall was tested by marking the locations of objects on a map of the arena (Abstract recall) and then by replacing the objects in the arena (Real recall). Two component errors were studied by calculating the Location Error (LE), independent of the object identity and the configuration error by finding the best match to the presented configuration. The RH group was impaired relative to the NC for nearly all combinations of recall and error types. An impairment was observed in this group even for one object and it deepened sharply with an increasing object number. Damage to the right perirhinal or parahippocampal cortices did not add to the impairment. Deficits in the LH group were also observed, but less consistently. The data indicate that spatial memory is strongly but not exclusively lateralised to the right medial temporal lobe.
通过使用小规模二维（抽象）或大规模三维（真实）回忆条件，对内侧颞叶进行小范围单侧热损伤的受试者进行测试，以研究物体位置记忆。对4名左侧海马体（LH）损伤患者、10名右侧海马体（RH）损伤患者和9名匹配的正常对照（NC）进行了测试。六个任务水平以伪随机顺序呈现。在每个水平期间，受试者在直径为2.90米的圆形带帘幕场地的地面上观看一到六个不同物体，持续10秒。通过在场地地图上标记物体位置（抽象回忆），然后在场地中替换物体（真实回忆）来测试回忆。通过计算位置误差（LE）研究两个组成误差，位置误差与物体身份无关，通过找到与呈现配置的最佳匹配来研究配置误差。RH组在几乎所有回忆和误差类型组合方面相对于NC组受损。即使对于一个物体，该组也观察到损伤，并且随着物体数量增加损伤急剧加深。右侧嗅周皮质或海马旁皮质损伤并未加重损伤。LH组也观察到缺陷，但不太一致。数据表明，空间记忆强烈但并非唯一地定位于右侧内侧颞叶。
