Gore M A, Karmalkar R N, Kulkarni M G
Polymer Science and Engineering Group, Chemical Engineering Division, National Chemical Laboratory, Pune 411008, India.
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May 5;804(1):211-21. doi: 10.1016/j.jchromb.2003.12.028.
Molecularly imprinted polymers are being increasingly investigated as selective sorbents. For the recovery of cholesterol from aqueous media, the utility of the molecularly imprinted polymers has been limited by modest capacities and selectivities, especially when compared with alternative adsorbents reported for the binding of bile acids [Macromolecules 34 (2001) 1548]. This paper describes the use of cholesterol conjugated monomers and cross-linkers, which bind to the template cholesterol molecule by hydrophobic interactions. This leads to enhanced capacities and selectivities during the recovery of cholesterol from aqueous media. The templating effect is clearly seen in the enhanced capacity and selectivity in the retention of cholesterol vis-a-vis stigmasterol and testosterone.
分子印迹聚合物作为选择性吸附剂正受到越来越多的研究。对于从水性介质中回收胆固醇而言，分子印迹聚合物的效用受到适度的容量和选择性限制，特别是与报道的用于结合胆汁酸的替代吸附剂相比时[《大分子》34 (2001) 1548]。本文描述了使用胆固醇共轭单体和交联剂，它们通过疏水相互作用与模板胆固醇分子结合。这导致在从水性介质中回收胆固醇的过程中容量和选择性增强。相对于豆甾醇和睾酮，在胆固醇保留方面增强的容量和选择性中可以清楚地看到模板效应。
