van Dam P Sytze, Aleman André
Department of Internal medicine, Onze Lieve Vrouwe Gasthuis, PO Box 95500, 1090 HM Amsterdam, The Netherlands.
Eur J Pharmacol. 2004 Apr 19;490(1-3):87-95. doi: 10.1016/j.ejphar.2004.02.047.
Aging is associated with a decline in the activity of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. As aging also coincides with a decline in specific cognitive functions and as some of these dysfunctions are also observed in subjects with GH deficiency, it has been hypothesised that a causal relationship exists between the reduction in circulating GH and/or IGF-I and the observed cognitive deficits in the elderly. The present review summarises the available data concerning the possible relation between GH, IGF-I and cognitive performance, and regarding possible underlying pathophysiological mechanisms.
衰老与生长激素（GH）/胰岛素样生长因子-I（IGF-I）轴活性下降有关。由于衰老也与特定认知功能的下降同时出现，并且在生长激素缺乏的受试者中也观察到其中一些功能障碍，因此有人推测，循环中的GH和/或IGF-I减少与老年人中观察到的认知缺陷之间存在因果关系。本综述总结了关于GH、IGF-I与认知表现之间可能关系以及潜在病理生理机制的现有数据。
