Baba Hajime, Suzuki Toshihito, Arai Heii, Emson Piers C
Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan.
Neuroreport. 2004 Mar 22;15(4):677-80. doi: 10.1097/00001756-200403220-00020.
Recent evidence suggests that nitric oxide (NO) systems are affected in the pathophysiology of schizophrenia. We quantified levels of neuronal NO synthase (nNOS) and soluble guanylate cyclase (sGC) subunit mRNAs in the prefrontal cortex of post-mortem brains from individuals with schizophrenia and controls using real-time quantitative PCR, to determine whether levels of nNOS and sGC subunits are altered in 'schizophrenic' brains. Neuronal NOS expression in the prefrontal cortex was significantly higher in individuals with schizophrenia, whereas no significant changes were found in sGC subunit mRNAs in people with schizophrenia or in controls. Abnormalities of nNOS expression in the brain might contribute to the development of schizophrenia.
最近的证据表明，一氧化氮（NO）系统在精神分裂症的病理生理学中受到影响。我们使用实时定量PCR对精神分裂症患者和对照组死后大脑前额叶皮质中神经元型一氧化氮合酶（nNOS）和可溶性鸟苷酸环化酶（sGC）亚基mRNA的水平进行了定量，以确定“精神分裂症”大脑中nNOS和sGC亚基的水平是否发生改变。精神分裂症患者前额叶皮质中的神经元型一氧化氮合酶表达显著更高，而精神分裂症患者或对照组的sGC亚基mRNA未发现显著变化。大脑中nNOS表达异常可能导致精神分裂症的发生。
