Amirhassani Vahid, Hussen Bashdar Mahmud, Eslami Solat, Sayad Arezou, Ghafouri-Fard Soudeh
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Biochem Genet. 2024 Dec 10. doi: 10.1007/s10528-024-10986-0.
Schizophrenia is a mental condition that impairs several aspects of brain function and behavior. Recent investigations highlighted abnormal function of numerous genes in this context. Notably, genes that affect oxidative stress and neuron damage were the focus of several studies. In an attempt to find a biomarker that can be quantified in the peripheral blood, we assessed blood expression of three lncRNAs that were associated with these processes in patients with schizophrenia and matched controls. We observed a statistically significant downregulation of SNHG5 in the patient group compared to healthy controls, with P-values of < 0.0001, 0.0008, and 0.003 in total, male, and female patients, respectively. LINC-PINT was also found to be down-regulated in all comparisons between patients and controls with P-values of < 0.0001, < 0.0001 and = 0.01, in total, male, and female patients, respectively. However, statistical analyses disclosed no notable difference in the expression of TP53TG1 between study subgroups. Most notably, LINC-PINT and SNHG5 could discriminate between patients and controls with acceptable AUC and specificity values. Cumulatively, the results of this study propose down-regulation of LINC-PINT and SNHG5 as a possible peripheral indicator of the presence of schizophrenia.
精神分裂症是一种损害大脑功能和行为多个方面的精神疾病。最近的研究突出了在这种情况下众多基因的异常功能。值得注意的是，影响氧化应激和神经元损伤的基因是多项研究的重点。为了寻找一种可在外周血中定量的生物标志物，我们评估了精神分裂症患者和匹配对照组中与这些过程相关的三种长链非编码RNA（lncRNA）的血液表达情况。我们观察到，与健康对照组相比，患者组中SNHG5的表达在统计学上显著下调，总患者、男性患者和女性患者的P值分别为<0.0001、0.0008和0.003。在患者与对照组的所有比较中，还发现LINC-PINT下调，总患者、男性患者和女性患者的P值分别为<0.0001、<0.0001和=0.01。然而，统计分析显示研究亚组之间TP53TG1的表达没有显著差异。最值得注意的是，LINC-PINT和SNHG5能够以可接受的曲线下面积（AUC）和特异性值区分患者和对照组。累积来看，本研究结果表明LINC-PINT和SNHG5的下调可能是精神分裂症存在的外周指标。
