Department of Biology, School of Sciences and Humanities, Nazarbayev University, Kabanbay Batyr 53, Astana 010000, Kazakhstan.
Int J Mol Sci. 2024 Jul 17;25(14):7809. doi: 10.3390/ijms25147809.
Vitamin D, obtained from diet or synthesized internally as cholecalciferol and ergocalciferol, influences bodily functions through its most active metabolite and the vitamin D receptor. Recent research has uncovered multiple roles for vitamin D in the central nervous system, impacting neural development and maturation, regulating the dopaminergic system, and controlling the synthesis of neural growth factors. This review thoroughly examines these connections and investigates the consequences of vitamin D deficiency in neurological disorders, particularly neurodegenerative diseases. The potential benefits of vitamin D supplementation in alleviating symptoms of these diseases are evaluated alongside a discussion of the controversial findings from previous intervention studies. The importance of interpreting these results cautiously is emphasised. Furthermore, the article proposes that additional randomised and well-designed trials are essential for gaining a deeper understanding of the potential therapeutic advantages of vitamin D supplementation for neurological disorders. Ultimately, this review highlights the critical role of vitamin D in neurological well-being and highlights the need for further research to enhance our understanding of its function in the brain.
维生素 D 可通过饮食获得，也可在体内由胆钙化醇和麦角钙化醇合成，其最活跃的代谢物和维生素 D 受体影响着身体的各种功能。最近的研究揭示了维生素 D 在中枢神经系统中的多种作用，影响着神经发育和成熟、调节多巴胺能系统，并控制神经生长因子的合成。本综述全面探讨了这些关联，并研究了维生素 D 缺乏在神经紊乱，特别是神经退行性疾病中的后果。本文还评估了维生素 D 补充在缓解这些疾病症状方面的潜在益处，同时讨论了先前干预研究中存在争议的结果。强调了谨慎解释这些结果的重要性。此外，本文还提出需要更多的随机和精心设计的试验，以深入了解维生素 D 补充对神经紊乱的潜在治疗优势。综上所述，本综述强调了维生素 D 在神经健康中的关键作用，并突出了需要进一步研究以增强我们对其在大脑中功能的理解。
