Alvarez-Ruiz S, Peñas P F, Fernández-Herrera J, Sánchez-Pérez J, Fraga J, García-Díez A
Department of Dermatology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006 Madrid, Spain.
J Eur Acad Dermatol Venereol. 2004 May;18(3):310-3. doi: 10.1111/j.1468-3083.2004.00872.x.
In the last years, granulocyte and granulocyte-macrophage colony-stimulating factors (G-CSF and GM-CSF) are being increasingly used and several cutaneous eruptions have been reported in relation to these treatments. In 1991 Horn et al. described three patients with maculopapular eruption that paralleled the time of infusion of GM-CSF. Two of the cases showed an increase in the number and size of macrophages in the biopsy specimen. Since then, several cases have been reported showing this histopathological alteration that has been considered characteristic of reaction to G-CSF or GM-CSF. Although maculopapular eruption with enlarged macrophages can appear after chemotherapy treatment, we have found that the presentation of this eruption after the beginning of cytokine treatment is suggestive of the involvement of G-CSF and GM-CSF in the eruption. We described eight cases of patients treated with G-CSF or GM-CSF that developed maculopapular eruptions with enlarged macrophages.
在过去几年中，粒细胞集落刺激因子和粒细胞巨噬细胞集落刺激因子（G-CSF和GM-CSF）的使用越来越多，并且已有数例与这些治疗相关的皮肤疹的报道。1991年，霍恩等人描述了3例斑丘疹患者，这些皮疹与GM-CSF输注时间平行。其中2例病例的活检标本显示巨噬细胞数量和大小增加。从那时起，已有数例病例报道显示这种组织病理学改变，这被认为是对G-CSF或GM-CSF反应的特征。尽管化疗后可出现伴有巨噬细胞增大的斑丘疹，但我们发现细胞因子治疗开始后出现这种皮疹提示G-CSF和GM-CSF参与了皮疹的发生。我们描述了8例接受G-CSF或GM-CSF治疗的患者，他们出现了伴有巨噬细胞增大的斑丘疹。
