Valks R, Vargas E, Munõz E, Fernández-Herrera J, Garcia-Diéz A, Fraga J
Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain.
J Cutan Pathol. 1998 May;25(5):259-64. doi: 10.1111/j.1600-0560.1998.tb01730.x.
A histologically distinct maculopapular eruption has been associated with the use of recombinant forms of granulocyte and granulocyte-macrophage colony-stimulating factors (GCSF and GMCSF). One of the most distinctive features was an increase in the number and the size of dermal macrophages, which was proposed as a clue to diagnosis of these cytokine-induced dermatoses. We describe 8 patients who received chemotherapy and who developed a maculopapular eruption, of which histological examination showed an increase in the number and the size of dermal macrophages. Three patients had also received GM-CSF or G-CSF, before the onset of rash, but 5 patients had not. In conclusion, an increase in the number and the size of dermal macrophages is not specific for the reaction to GM-CSF or G-CSF, and may also be observed in patients receiving chemotherapy.
一种组织学上独特的斑丘疹皮疹与使用重组形式的粒细胞和粒细胞-巨噬细胞集落刺激因子（GCSF和GMCSF）有关。最显著的特征之一是真皮巨噬细胞数量和大小增加，这被认为是诊断这些细胞因子诱导的皮肤病的线索。我们描述了8例接受化疗并出现斑丘疹皮疹的患者，组织学检查显示真皮巨噬细胞数量和大小增加。3例患者在皮疹出现前还接受了GM-CSF或G-CSF，但5例患者未接受。总之，真皮巨噬细胞数量和大小增加并非GM-CSF或G-CSF反应所特有，在接受化疗的患者中也可能观察到。
