阿尔茨海默病中的执行功能障碍
Executive dysfunction in Alzheimer disease.
作者信息
Swanberg Margaret M, Tractenberg Rochelle E, Mohs Richard, Thal Leon J, Cummings Jeffrey L
机构信息
Department of Neurology, David Geffen School of Medicine at UCLA, 90095-1769, USA.
出版信息
Arch Neurol. 2004 Apr;61(4):556-60. doi: 10.1001/archneur.61.4.556.
BACKGROUND
Executive dysfunction (EDF) is common in Alzheimer disease (AD); however, its relationship to other symptoms is difficult to assess in patients with AD.
OBJECTIVES
To determine the prevalence of EDF and study its relationship to cognitive, functional, and neuropsychiatric symptoms in patients with AD.
DESIGN, SETTING, AND PATIENTS: A retrospective analysis of data from participants in the English Instruments Protocol of the Alzheimer's Disease Cooperative Study. Subjects were drawn from a sample of patients evaluated at tertiary referral centers.
RESULTS
A total of 64% of AD patients were classified as having EDF. Patients with EDF performed worse on tests of cognition (P <.001), dementia severity (P <.001), and activities of daily living (P =.01) and had more frequent symptoms of psychosis (P =.03) with greater emergence during the 12-month interval (P =.03) compared with patients with normal executive function. Less than 30% of the variance in executive function performance was explained by cognitive measures.
CONCLUSION
These findings support the assessment of executive function in persons with AD and the importance of frontal lobe dysfunction in AD.
背景
执行功能障碍（EDF）在阿尔茨海默病（AD）中很常见；然而，在AD患者中，其与其他症状的关系难以评估。
目的
确定AD患者中EDF的患病率，并研究其与AD患者认知、功能和神经精神症状的关系。
设计、设置和患者：对阿尔茨海默病协作研究英语工具协议参与者的数据进行回顾性分析。受试者来自在三级转诊中心接受评估的患者样本。
结果
共有64%的AD患者被归类为有EDF。与执行功能正常的患者相比，有EDF的患者在认知测试（P<.001）、痴呆严重程度（P<.001）和日常生活活动（P=.01）方面表现更差，且有更频繁的精神病症状（P=.03），在12个月期间出现得更多（P=.03）。执行功能表现中不到30%的变异可由认知测量解释。
结论
这些发现支持对AD患者进行执行功能评估以及额叶功能障碍在AD中的重要性。
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