Wang Lihong V
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, TX 77843-3120, USA.
Dis Markers. 2003;19(2-3):123-38. doi: 10.1155/2004/478079.
This article reviews two types of ultrasound-mediated biophotonic imaging-acousto-optical tomography (AOT, also called ultrasound-modulated optical tomography) and photo-acoustic tomography (PAT, also called opto-acoustic or thermo-acoustic tomography)-both of which are based on non-ionizing optical and ultrasonic waves. The goal of these technologies is to combine the contrast advantage of the optical properties and the resolution advantage of ultrasound. In these two technologies, the imaging contrast is based primarily on the optical properties of biological tissues, and the imaging resolution is based primarily on the ultrasonic waves that either are provided externally or produced internally, within the biological tissues. In fact, ultrasonic mediation overcomes both the resolution disadvantage of pure optical imaging in thick tissues and the contrast and speckle disadvantages of pure ultrasonic imaging. In our discussion of AOT, the relationship between modulation depth and acoustic amplitude is clarified. Potential clinical applications of ultrasound-mediated biophotonic imaging include early cancer detection, functional imaging, and molecular imaging.
本文综述了两种超声介导的生物光子成像技术——声光断层扫描（AOT，也称为超声调制光学断层扫描）和光声断层扫描（PAT，也称为光声或热声断层扫描）——这两种技术均基于非电离的光波和超声波。这些技术的目标是将光学特性的对比度优势与超声的分辨率优势结合起来。在这两种技术中，成像对比度主要基于生物组织的光学特性，而成像分辨率主要基于外部提供的或生物组织内部产生的超声波。事实上，超声介导克服了厚组织中纯光学成像的分辨率劣势以及纯超声成像的对比度和散斑劣势。在我们对AOT的讨论中，阐明了调制深度与声振幅之间的关系。超声介导的生物光子成像的潜在临床应用包括早期癌症检测、功能成像和分子成像。
