Klepzig H, Kaltenbach M
Abteilung für Kardiologie Zentrums der Inneren Medizin Klinikums der Johann-Wolfgang-Goethe-Universität, Frankfurt, Main.
Z Kardiol. 1992 Jul;81(7):347-53.
Numerous studies have confirmed a positive correlation between serum cholesterol levels and the occurrence of coronary artery disease. Lowering cholesterol by 1% is accompanied by a reduction of coronary events by 2%. The rate of fatal coronary events is not significantly influenced. Coronary angiography demonstrated only a mild average reduction of coronary lesions after cholesterol-lowering therapy. This might be explained by the low lipid content of a coronary plaque (5-15%). The majority of intervention trials revealed an increase of the extracardiac mortality in treatment groups. Thus, up to the present, it remains unproven that cholesterol-lowering therapy leads to an increase in life expectancy.
大量研究证实血清胆固醇水平与冠状动脉疾病的发生之间存在正相关。胆固醇水平降低1%，冠状动脉事件发生率会降低2%。致命性冠状动脉事件的发生率未受到显著影响。冠状动脉造影显示，降脂治疗后冠状动脉病变仅平均轻度减少。这可能是由于冠状动脉斑块的脂质含量较低（5%-15%）。大多数干预试验表明治疗组的心外死亡率有所增加。因此，截至目前，降脂治疗能否延长预期寿命仍未得到证实。
