Klepzig H, Kaltenbach M
Abteilung für Kardiologie, Universität Frankfurt a. M.
Versicherungsmedizin. 1992 Dec 1;44(6):192-4.
Epidemiologic surveys reveal a positive correlation between serum cholesterol levels and the incidence of coronary artery disease. Intervention trials demonstrated that a reduction of serum cholesterol by 1% results in a decrease of coronary non-fatal events by 2%. Fatal coronary events remain almost uninfluenced. On the other side, several intervention trials showed an excess mortality from non-cardiac causes in the therapy groups (i.e. malignant tumors, suicides, accidents). Thus, until now no prolongation of life expectancy could be verified by cholesterol lowering measures.
流行病学调查显示血清胆固醇水平与冠状动脉疾病的发病率之间呈正相关。干预试验表明，血清胆固醇降低1%可使冠状动脉非致命事件减少2%。致命性冠状动脉事件几乎不受影响。另一方面，多项干预试验显示治疗组存在非心脏原因导致的额外死亡率（即恶性肿瘤、自杀、事故）。因此，到目前为止，尚未通过降低胆固醇的措施证实预期寿命有所延长。
