Chang Mary Wu, Kaufmann Julie M, Orlow Seth J, Cohen David E, Mobini Narciss, Kamino Hideko
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
J Am Acad Dermatol. 2004 May;50(5 Suppl):S93-6. doi: 10.1016/s0190-9622(03)02785-3.
Granular parakeratosis is an acquired, idiopathic disorder of keratinization typified by retention hyperkeratosis. It usually occurs in women at intertriginous sites. There have been only 2 reports of infants with granular parakeratosis to our knowledge. We describe 3 additional infants with granular parakeratosis. We demonstrate that infantile granular parakeratosis exhibits 2 clinical patterns: bilateral linear plaques in the inguinal folds; and erythematous geometric plaques underlying pressure points from the diaper. A thick, flakelike scale is present in both forms and is characteristic. Diaper wearing appears to play an important role in the genesis of infantile granular parakeratosis but the mechanisms are unclear. Therapeutic responsiveness to topical agents is ambiguous, however, spontaneous clearance after months to 1 year appears to be the rule.
颗粒状角化不全是一种后天性、特发性的角化异常疾病，以角质潴留性角化过度为特征。它通常发生在女性的摩擦部位。据我们所知，仅有2例婴儿患颗粒状角化不全的报道。我们描述另外3例患颗粒状角化不全的婴儿。我们证明婴儿颗粒状角化不全有两种临床模式：腹股沟皱襞处的双侧线状斑块；以及尿布压迫点下方的红斑几何形状斑块。两种形式均有厚的片状鳞屑，这是其特征。穿尿布似乎在婴儿颗粒状角化不全的发病中起重要作用，但机制尚不清楚。对局部用药的治疗反应不明确，然而，数月至1年后自发消退似乎是规律。
