Li Huixian, Li Hui, Tian Qinghua, Fang Xiangang
Department of Sterilization Supply, Weifang People's Hospital, Weifang, Shandong, People's Republic of China.
Department of Dermatology, Weifang People's Hospital, Weifang, Shandong, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Apr 1;16:853-857. doi: 10.2147/CCID.S401799. eCollection 2023.
Granular parakeratosis is a rare dermatosis characterized by erythematous scaly patches or papules, and plaques, often involving intertriginous areas. In this work, a 73-year-old Chinese male patient presented with a 6-month history of pruritic verrucous papules on the bilateral groin. A skin biopsy was performed and revealed the following: the horny layer showed highly compact hyperkeratosis and parakeratosis with basophilic granules; the epidermis showed obvious acanthosis with psoriasiform hyperplasia. The final diagnosis was verrucous granular parakeratosis. We also reviewed the progress in nomenclature, etiology, clinical manifestations, differential diagnosis and treatment. Different clinical manifestations may represent different clinical entities. Dermatologists should differentiate it from other diseases to make a correct diagnosis. Treatment options should be based on the variable etiologies and clinical manifestations.
颗粒状角化不全症是一种罕见的皮肤病，其特征为红斑鳞屑性斑块或丘疹及斑块，常累及皮肤褶皱部位。在本研究中，一名73岁的中国男性患者双侧腹股沟出现瘙痒性疣状丘疹6个月。进行了皮肤活检，结果如下：角质层显示高度致密的角化过度和角化不全，并伴有嗜碱性颗粒；表皮显示明显的棘层肥厚伴银屑病样增生。最终诊断为疣状颗粒状角化不全症。我们还回顾了其命名、病因、临床表现、鉴别诊断及治疗方面的进展。不同的临床表现可能代表不同的临床实体。皮肤科医生应将其与其他疾病相鉴别以做出正确诊断。治疗方案应基于不同的病因和临床表现。
