Ning Ke, Li Lei, Liao Mingxia, Liu Baosong, Mielke John G, Chen Yonghong, Duan Ying, El-Hayek Youssef H, Wan Qi
Division of Cellular & Molecular Biology, Toronto Western Research Institute, University Health Network, and Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Nat Neurosci. 2004 May;7(5):489-90. doi: 10.1038/nn1236. Epub 2004 Apr 18.
The type A GABA receptors are thought to mediate synchronization of clock cell activity within the suprachiasmatic nuclei (SCN). Here we report that casein kinases I epsilon and delta (CKI epsilon and CKI delta), the crucial clock regulators, form a complex with GABA(A) receptors and inhibit the receptors' function within the SCN according to a circadian rhythm. These results indicate that circadian variation of the kinase-receptor association may mediate regulation of GABA(A) receptor function by CKI epsilon-CKI delta in the SCN.
A型γ-氨基丁酸（GABA）受体被认为可介导视交叉上核（SCN）内生物钟细胞活动的同步化。在此我们报告，酪蛋白激酶Iε和δ（CKIε和CKIδ）这两种关键的生物钟调节因子，与GABA(A)受体形成复合物，并根据昼夜节律抑制SCN内该受体的功能。这些结果表明，激酶-受体结合的昼夜变化可能介导了SCN中CKIε-CKIδ对GABA(A)受体功能的调节。
