Iwasa M A, Kariwa H, Cui B-Z, Lokugamage K, Lokugamage N, Hagiya T, Mizutani T, Takashima I
Japan Health Sciences Foundation, Tokyo, Japan.
Arch Virol. 2004 May;149(5):929-41. doi: 10.1007/s00705-003-0255-x. Epub 2003 Dec 23.
To elucidate the mode of transmission of Puumala-related hantavirus in a population of gray red-backed voles, Clethrionomys rufocanus bedfordiae, in Hokkaido, Japan, we analyzed the kin structure and dispersal patterns of individual voles using microsatellite and mitochondrial DNA markers. Siblings or dam/offsprings was identified within the population based on the relatedness calculation with the microsatellite data. The pairwise relatedness values obtained could reveal kinship among all vole individuals within the population. Based on the assessment of kinship, we did not find a positive relationship between hantavirus transmission and close kinship. Males infected with the hantavirus carried a relatively uncommon mitochondrial haplotype. However, these infected males shared low relatedness values and were not considered closely related, i.e., they were not siblings or parent/offspring. These observations imply that hantavirus transmission in the vole population may not be related to close kinship but by random horizontal infection.
为了阐明日本北海道棕背䶄指名亚种群体中普马拉相关汉坦病毒的传播方式，我们使用微卫星和线粒体DNA标记分析了个体田鼠的亲缘结构和扩散模式。根据微卫星数据的相关性计算，在群体中识别出了兄弟姐妹或母/子关系。获得的成对相关性值可以揭示群体中所有田鼠个体之间的亲缘关系。基于亲缘关系的评估，我们没有发现汉坦病毒传播与近亲关系之间存在正相关。感染汉坦病毒的雄性携带相对罕见的线粒体单倍型。然而，这些受感染的雄性之间的相关性值较低，不被认为是近亲，即他们不是兄弟姐妹或亲子关系。这些观察结果表明，田鼠群体中的汉坦病毒传播可能与近亲关系无关，而是通过随机水平感染传播。
