Ou Ruwei, Song Wei, Wei Qianqian, Chen Ke, Cao Bei, Hou Yanbing, Zhao Bi, Shang Huifang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Parkinsons Dis. 2016;2016:9730319. doi: 10.1155/2016/9730319. Epub 2016 Jun 5.
Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson's disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of "sleep/fatigue," "mood/apathy," "attention/memory," "gastrointestinal," "sexual dysfunction," and "miscellaneous" domains in PSP group were significantly higher than those in HC group (P < 0.05). The frequency of "mood/apathy," "attention/memory," and "sexual dysfunction" domains and the severity of "attention/memory" and "gastrointestinal" domains in PSP group were significantly higher than those in PD group (P < 0.05). The "attention/memory" domain in PSP had a significant but weak-to-moderate correlation with age (R = 0.387, P = 0.046) and onset age (R = 0.406, P = 0.036). Conclusions. NMS are common in PSP patients. Patients with PSP seem to be subjected to more frequent and severe specific NMS compared to healthy aging subjects and PD patients. Older PSP patients and late-onset patients are likely to be subjected to cognitive decline.
目的。探讨进行性核上性麻痹（PSP）中非运动症状（NMS）的临床相关性及其与健康对照和帕金森病（PD）患者的差异。方法。本病例对照研究纳入了27例PSP患者、27例年龄和性别匹配的健康对照（HC）以及27例年龄和性别匹配的PD患者。使用非运动症状量表（NMSS，包括9个领域）评估NMS。结果。所有PSP患者均报告有NMS。PSP组“睡眠/疲劳”“情绪/淡漠”“注意力/记忆”“胃肠道”“性功能障碍”和“其他”领域的频率和严重程度显著高于HC组（P<0.05）。PSP组“情绪/淡漠”“注意力/记忆”和“性功能障碍”领域的频率以及“注意力/记忆”和“胃肠道”领域的严重程度显著高于PD组（P<0.05）。PSP中的“注意力/记忆”领域与年龄（R = 0.387，P = 0.046）和发病年龄（R = 0.406，P = 0.036）呈显著但弱至中度相关。结论。NMS在PSP患者中很常见。与健康老年人和PD患者相比，PSP患者似乎更容易出现更频繁、更严重的特定NMS。年龄较大的PSP患者和晚发型患者可能会出现认知衰退。
