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[立陶宛的艾滋病研究]

[Studies of AIDS in Lithuania].

作者信息

Chaplinskas S A, Pikelite R L, Shiakshtialene N R, Chaponene N B, Rodova M N, Kozhevnikova L K, Iakhno K V, Marushevskaia M V, Karamov E V, Zhdanov V M

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1992 Mar(3):34-6.

PMID:1509843
Abstract

The seroepidemiological survey of 400,000 persons aged 20-40 years and belonging to different AIDS risk groups, as well as blood donors, for the presence of antibodies to HIV has been carried out on the territory of Lithuania. This investigation has been made with the use of the assay systems "Antigen", "Peptoscreen" and "Vector" manufactured in the USSR, as well as commercial assay systems from foreign manufacturers, such as Du Pont de Nemours Inc., Organon N. V., Abbott Laboratories, Serodia. The comparison of the results thus obtained has revealed that high frequency of false positive results is characteristic of all assay systems under study, including immunoblotting. These data indicate that test systems based on different acting principles should be used for the detection of anti-HIV antibodies. For the first time a HIV-infected resident of Lithuania has been detected. The investigation carried out in Lithuania has shown that HIV infection is not widely spread in this region, but due to some objective reasons this does not preclude the necessity of the constant epidemiological surveillance of this infection throughout this territory in order to bar the way to this infection.

摘要

在立陶宛境内,对40万名年龄在20至40岁之间、属于不同艾滋病风险群体的人员以及献血者进行了血清流行病学调查,以检测其是否存在HIV抗体。此次调查使用了苏联生产的“抗原”“肽筛选”和“载体”检测系统,以及来自外国制造商的商业检测系统,如杜邦公司、欧加农公司、雅培实验室、血清学检测试剂。对所获结果的比较显示,包括免疫印迹法在内的所有研究中的检测系统都存在较高频率的假阳性结果。这些数据表明,应使用基于不同作用原理的检测系统来检测抗HIV抗体。首次检测到一名立陶宛HIV感染居民。在立陶宛开展的调查表明,HIV感染在该地区并未广泛传播,但由于一些客观原因,这并不排除在整个领土持续开展这种感染的流行病学监测以阻止其传播的必要性。

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