Tswana S A, Moyo S R, Nyström L, Blomerg J
Department of Medical Microbiology, University of Zimbabwe Medical School, Harare.
Cent Afr J Med. 1993 Oct;39(10):198-201.
Sera from 871 AIDS and AIDS related complex patients were used to evaluate four ELISA and one agglutination assays. Commercial tests compared were Abbot, Wellcoyzyme, Biotest, Du Pont and Serodia. Wellcozyme and Serodia had the highest sensitivity (96.8 pc and 98.8 pc respectively) but the lowest specificity (53.3 pc and 46.5 pc respectively). Du Pont was the least sensitive test (89.1pc). Biotest and Abbot were comparable--Biotest had a higher sensitivity (93.2pc as compared with 90.6pc) but Abbot had a higher specificity (94.1 pc as compared with 89.1 pc). Thus, Abbott and Biotest both had a satisfactory high sensitivity and specificity and could thereby be recommended for use in screening of HIV-1 antibodies in south east Africa.
使用871名艾滋病及艾滋病相关综合征患者的血清来评估四种酶联免疫吸附测定（ELISA）和一种凝集试验。所比较的商业检测试剂有雅培（Abbot）、Wellcoyzyme、比奥泰克（Biotest）、杜邦（Du Pont）和富士瑞必欧（Serodia）。Wellcozyme和富士瑞必欧的灵敏度最高（分别为96.8%和98.8%），但特异性最低（分别为53.3%和46.5%）。杜邦是灵敏度最低的检测试剂（89.1%）。比奥泰克和雅培相当——比奥泰克的灵敏度更高（93.2%，而雅培为90.6%），但雅培的特异性更高（94.1%，而比奥泰克为89.1%）。因此，雅培和比奥泰克都具有令人满意的高灵敏度和特异性，从而可推荐用于在非洲东南部筛查HIV-1抗体。
Zotero 插件