Wang Chuan, Xu Xin, Yu Qian, Liu Hengchuan
Shool of Public Health, West China Medical Center of Sichuan University, Chengdu 610041, China.
Wei Sheng Yan Jiu. 2004 Jan;33(1):42-4, 48.
To study the synergetic germicidal effect of ulstrasonic with glutaraldehyde and the feasibility of combining ulstrasonic and glutaraldehyde to disinfect endocopes and medical instruments.
We determined the respective and the synergetic killing rates of Bacillus subtilis var. niger of ulstrasonic and glutaraldehyde using quantitative suspenion germicidal tests and simulated on-the-spot tests.
In suspenion germicidal tests, because of the synergetic germicidal effect, the concentration of glutaraldehyde needed for sterilize spores was decreased from 20 mg/ml to 5 mg/ml for the same killing time(4 h), and when the concentrations were still 20 mg/ml, its killing time was shorten from 4 h to 1 h. Further more, the solutions containing 5 mg/ml glutaraldehyde could sterilize spores of Bacillus subtilis var. niger in 2 h. In the simulated on-the-spot tests, the concentration of glutaraldehyde needed for sterilization was decreased from 20 mg/ml to 5 mg/ml and its killing time was shorten from 4 h to 1 h under the synergetic germicidal effect.
It indicats the feasibility of combining ulstrasonic and glutaraldehyde to disinfect instruments in clinic.
研究超声波与戊二醛协同杀菌效果以及两者联用对内镜及医疗器械消毒的可行性。
采用定量悬液杀菌试验和模拟现场试验，测定超声波与戊二醛对枯草杆菌黑色变种芽胞的各自杀菌率及协同杀菌率。
在悬液杀菌试验中，由于协同杀菌作用，在相同杀菌时间（4小时）下，杀灭芽胞所需戊二醛浓度从20毫克/毫升降至5毫克/毫升；当浓度仍为20毫克/毫升时，杀菌时间从4小时缩短至1小时。此外，含5毫克/毫升戊二醛的溶液在2小时内可杀灭枯草杆菌黑色变种芽胞。在模拟现场试验中，在协同杀菌作用下，消毒所需戊二醛浓度从20毫克/毫升降至5毫克/毫升，杀菌时间从4小时缩短至1小时。
表明超声波与戊二醛联用对临床器械消毒具有可行性。
