Angelillo I F, Bianco A, Nobile C G, Pavia M
Medical School, University of Catanzaro, Italy.
Lett Appl Microbiol. 1998 Nov;27(5):292-6.
The antimicrobial and sporicidal activities in vitro and in vivo of 1% peroxygen (Virkon) and 2% alkaline glutaraldehyde (Asporin) were evaluated on dental instruments before and after cleaning. The in vitro antimicrobial activity against vegetative bacteria, bacterial spores and fungi indicated that glutaraldehyde is more active against these organisms than peroxygen. Asporin killed all vegetative bacteria within 1 min after cleaning, whereas Virkon was active, in the majority of cases, within 15 min and obtained a greater than 10(5)-fold reduction in count before killing for the vast majority of instruments, and for all micro-organisms. The spores of Bacillus subtilis were killed by Asporin within 4-5 h after cleaning, whereas Virkon required almost 20 h. A meticulous instrument cleaning process followed by an appropriate disinfection treatment assures a shorter disinfection time. Asporin should be recommended for chemical sterilization or high-level disinfection of dental instruments, and Virkon, if only disinfection is required, would seem to be a possible alternative, even if used with a higher exposure time.
对清洁前后的牙科器械，评估了1%过氧乙酸（卫可）和2%碱性戊二醛（阿斯波林）的体外和体内抗菌及杀孢子活性。针对营养菌、细菌芽孢和真菌的体外抗菌活性表明，戊二醛对这些微生物的活性比过氧乙酸更强。阿斯波林在清洁后1分钟内可杀灭所有营养菌，而在大多数情况下，卫可在15分钟内有活性，并且绝大多数器械在杀灭前菌数减少超过10⁵倍，对所有微生物均如此。枯草芽孢杆菌的芽孢在清洁后4 - 5小时被阿斯波林杀灭，而卫可则需要近20小时。细致的器械清洁过程之后进行适当的消毒处理可确保消毒时间更短。阿斯波林应被推荐用于牙科器械的化学灭菌或高水平消毒，而如果仅需要消毒，卫可似乎是一种可能的替代选择，即使使用时暴露时间更长。
