Umar Saleem A, Bhattacharjee Pradip, Brodell Robert T
Forum Health, Youngstown, OH, USA.
J Drugs Dermatol. 2004 Mar-Apr;3(2):200-3.
Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known cure. Current therapeutic strategies attempt to suppress Hailey-Hailey outbreaks and allow the patient to live comfortably with this condition. We have found that applying topical tacrolimus 0.1% ointment (Protopic) twice a day to affected areas is an excellent way to control Hailey-Hailey disease. In addition to effectively controlling Hailey-Hailey outbreaks, tacrolimus is a relatively safe and noninvasive mode of treatment, without significant side effects. We recommend intermittent therapy with clobetasol propionate 0.05% foam (Olux Foam) for patients who break through suppressive therapy with tacrolimus a few times per year. In patients with frequent outbreaks of Hailey-Hailey disease despite suppressive therapy with tacrolimus, we recommend alternating the tacrolimus with clobetasol propionate 0.05% foam every 6 weeks.
黑利-黑利病，即家族性良性慢性天疱疮，是一种尚无已知治愈方法的慢性疾病。当前的治疗策略旨在抑制黑利-黑利病的发作，使患者能舒适地与这种疾病共处。我们发现，每天两次在患处涂抹0.1%的外用他克莫司软膏（普特彼）是控制黑利-黑利病的一种极佳方法。除了能有效控制黑利-黑利病的发作外，他克莫司是一种相对安全且非侵入性的治疗方式，没有明显副作用。对于每年有几次突破他克莫司抑制治疗的患者，我们建议间歇性使用0.05%丙酸氯倍他索泡沫剂（奥洛克斯泡沫剂）。对于尽管使用他克莫司进行抑制治疗但仍频繁发作黑利-黑利病的患者，我们建议每6周交替使用他克莫司和0.05%丙酸氯倍他索泡沫剂。
