Koeyers Wendy Jane, Van Der Geer Simone, Krekels Gertruud
Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
J Dermatolog Treat. 2008;19(4):251-4. doi: 10.1080/09546630801955135.
Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed.
To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease.
The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport was started in all six cases.
Marked improvement of the lesions was achieved with few side effects in all patients.
Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.
广泛型黑利-黑利病通常对传统的局部和全身治疗有抵抗性。全身治疗和消融治疗有许多副作用和/或高复发率。因此，需要一种安全有效的替代治疗方法。
评估A型肉毒毒素治疗广泛型黑利-黑利病的有效性。
对6例对多种治疗方案均有抵抗性的广泛型黑利-黑利病患者的病例进行研究并描述。所有6例患者均开始使用A型肉毒毒素/丽舒妥进行辅助治疗。
所有患者的皮损均有显著改善，且副作用很少。
A型肉毒毒素是广泛型黑利-黑利病的一种安全有效的辅助治疗方法。
