Rocha Paris F, Fidalgo A, Baptista J, Caldas L Lopes, Ferreira A
Dermatology Department, Desterro Hospital, Lisbon, Portugal.
Int J Tissue React. 2005;27(4):151-4.
Hailey-Hailey disease, or familial benign chronic pemphigus, is a rare relapsing-remitting autosomal-dominant epidermal blistering disease. It preferentially affects females and is characterized by recurrent vesicles and erosions in the intertriginous areas. There are several topical corticosteroid therapeutic options, which are often limited in their use by their secondary effects and localization of the lesions. We report a case of a 60-year-old woman with Hailey-Hailey disease involving axillary, groin, cervical, antecubital, inframammary and abdominal folds. She was treated with 0.1% tacrolimus ointment, applied twice daily, with clinical improvement in 2 weeks and total remission in 4 weeks. She remains asymptomatic after a 10-month follow-up period.
黑利-黑利病，即家族性良性慢性天疱疮，是一种罕见的常染色体显性复发性表皮水疱病。该病更易累及女性，其特征为在皮肤褶皱部位反复出现水疱和糜烂。有多种局部用皮质类固醇治疗方案，但这些方案的使用常因副作用和病变部位而受到限制。我们报告一例60岁患有黑利-黑利病的女性病例，病变累及腋窝、腹股沟、颈部、肘前、乳房下和腹部褶皱处。她接受了0.1%他克莫司软膏治疗，每天涂抹两次，2周后临床症状改善，4周后完全缓解。经过10个月的随访期，她仍无症状。
