Blackwood N J, Bentall R P, Ffytche D H, Simmons A, Murray R M, Howard R J
Department of Psychological Medicine, Institute of Psychiatry, London.
Psychol Med. 2004 May;34(4):591-6. doi: 10.1017/S0033291703008997.
People with persecutory delusions regard ambiguous data in the social domain as self-relevant and selectively attend to threatening information. This study aimed to characterize these social cognitive biases in functional neuroanatomical terms.
Eight schizophrenic patients with active persecutory delusions and eight matched normal controls underwent functional magnetic resonance imaging while determining the self-relevance of ambiguous self-relevant or unambiguous other-relevant neutral and threatening statements.
In determining self-relevance, the deluded subjects showed a marked absence of rostral-ventral anterior cingulate activation together with increased posterior cingulate gyrus activation in comparison to the normal subjects. The influence of threat on self-relevance determination did not yield statistically significant differences between deluded and normal subjects.
Abnormalities of cingulate gyrus activation while determining self-relevance suggest impaired self-reflection in the persecutory deluded state. This may contribute to persecutory belief formation and maintenance.
患有被害妄想症的人将社会领域中的模糊数据视为与自身相关，并选择性地关注威胁性信息。本研究旨在从功能性神经解剖学角度描述这些社会认知偏差。
八名患有活跃被害妄想症的精神分裂症患者和八名匹配的正常对照者接受了功能磁共振成像，同时确定模糊的自我相关或明确的他人相关的中性和威胁性陈述的自我相关性。
在确定自我相关性时，与正常受试者相比，妄想受试者的喙腹前扣带回激活明显缺失，同时后扣带回激活增加。威胁对自我相关性确定的影响在妄想和正常受试者之间没有产生统计学上的显著差异。
在确定自我相关性时扣带回激活异常表明在被害妄想状态下自我反思受损。这可能有助于被害妄想的形成和维持。
