Zhang Jian, Liu Tiantian, Shi Zhongyan, Tan Shuping, Suo Dingjie, Dai Chunyang, Wang Li, Wu Jinglong, Funahashi Shintaro, Liu Miaomiao
School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China.
School of Life Sciences, Beijing Institute of Technology, Beijing, China.
Front Aging Neurosci. 2022 Feb 7;14:754600. doi: 10.3389/fnagi.2022.754600. eCollection 2022.
Patients with bipolar disorder have deficits in self-referenced information. The brain functional connectivity during social cognitive processing in bipolar disorder is unclear. Electroencephalogram (EEG) was recorded in 23 patients with bipolar disorder and 19 healthy comparison subjects. We analyzed the time-frequency distribution of EEG power for each electrode associated with self, other, and font reflection conditions and used the phase lag index to characterize the functional connectivity between electrode pairs for 4 frequency bands. Then, the network properties were assessed by graph theoretic analysis. The results showed that bipolar disorder induced a weaker response power and phase lag index values over the whole brain in both self and other reflection conditions. Moreover, the characteristic path length was increased in patients during self-reflection processing, whereas the global efficiency and the node degree were decreased. In addition, when discriminating patients from normal controls, we found that the classification accuracy was high. These results suggest that patients have impeded integration of attention, memory, and other resources of the whole brain, resulting in a deficit of efficiency and ability in self-referential processing.
双相情感障碍患者在自我参照信息方面存在缺陷。双相情感障碍患者在社会认知加工过程中的脑功能连接尚不清楚。对23例双相情感障碍患者和19名健康对照者进行了脑电图（EEG）记录。我们分析了与自我、他人和字体反射条件相关的每个电极的EEG功率的时频分布，并使用相位滞后指数来表征4个频段电极对之间的功能连接。然后，通过图论分析评估网络特性。结果表明，在自我和他人反射条件下，双相情感障碍在全脑诱发的反应功率和相位滞后指数值较弱。此外，患者在自我反射加工过程中特征路径长度增加，而全局效率和节点度降低。此外，在区分患者与正常对照时，我们发现分类准确率很高。这些结果表明，患者全脑的注意力、记忆和其他资源的整合受到阻碍，导致自我参照加工的效率和能力不足。
