Hours Sandrine, Lejaille Michèle, Pozzi Delphine, Falaize Line, Zerah-Lancner Françoise, Raphael Jean-Claude, Lofaso Frédéric
Services de Réanimation Médicale, Physiologie-Explorations Fonctionnelles, et Centre d'Innovation Technologique Hôpital Raymond Poincaré, AP-HP, 92380 Garches, France.
Neuromuscul Disord. 2004 May;14(5):289-96. doi: 10.1016/j.nmd.2004.01.008.
Intensity of perceived inspiratory difficulty was investigated in 17 patients with severe respiratory insufficiency due to muscle disease, compared with healthy matched controls. Subjects breathed through a threshold valve generating a constant inspiratory negative pressure proportional to their maximal inspiratory pressure. Four load levels ranging from 10 to 40% of the maximal inspiratory pressure were applied in random order. Patients had significantly less perceived inspiratory difficulty than controls at each load level expressed as a percentage of maximal inspiratory pressure P < 0.001. However, when the load was expressed as the absolute value, the slope of the Borg scale score versus mouth pressure was similar in the two groups (P = 0.11). The ventilatory pattern remained unchanged in each group as the load increased. We conclude that in patients with myopathy, loads leading to respiratory muscle fatigue (40% of maximal inspiratory pressure) may fail to produce perceived inspiratory difficulty.
研究了17例因肌肉疾病导致严重呼吸功能不全的患者与健康对照者相比的感知吸气困难强度。受试者通过一个阈值阀呼吸，该阀产生与他们的最大吸气压力成比例的恒定吸气负压。以随机顺序施加四个负荷水平，范围从最大吸气压力的10%到40%。在每个负荷水平下，以最大吸气压力的百分比表示，患者的感知吸气困难明显低于对照组（P<0.001）。然而，当负荷以绝对值表示时，两组中Borg量表评分与口腔压力的斜率相似（P=0.11）。随着负荷增加，每组的通气模式保持不变。我们得出结论，在患有肌病的患者中，导致呼吸肌疲劳的负荷（最大吸气压力的40%）可能不会产生感知吸气困难。
