Mangelsdorff G, Borzone G, Leiva A, Martínez A, Lisboa C
Departamentos de Enfermedades Respiratorias y de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile.
Rev Med Chil. 2001 Jan;129(1):51-9.
The maximal pressure generated by inspiratory muscles (PIMax) is an index of their strength which is diminished in both chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). Although inspiratory muscle power output (IMPO), which includes both strength and velocity of shortening, has been shown to be reduced in COPD, there is no information regarding IMPO in CHF.
To measure IMPO in patients with CHF and COPD.
We studied 9 CHF patients with functional capacity II and III and 9 patients with severe COPD. Eight normal subjects of similar ages were included as controls. Power output was measured using the incremental threshold loading test.
Maximal IMPO was significantly reduced in both groups of patients. Power output developed with each increasing load was also diminished, basically as a consequence of a reduction in Vinsp. The degree of dyspnea at the end of the test was greater in COPD than in CHF patients and normal subjects. For a given level of power, dyspnea was also greater in patients than in normals subjects. There was no decrease in SpO2 during the test.
IMPO is equally reduced in COPD and CHF patients. Power output is better related to dyspnea than PIMax, probably because of the inclusion of shortening velocity.
吸气肌产生的最大压力(PIMax)是其力量的一个指标,在慢性阻塞性肺疾病(COPD)和慢性心力衰竭(CHF)中均会降低。尽管吸气肌功率输出(IMPO),包括力量和缩短速度,已被证明在COPD中会降低,但关于CHF中IMPO的信息尚无报道。
测量CHF和COPD患者的IMPO。
我们研究了9例功能能力为II级和III级的CHF患者以及9例重度COPD患者。纳入8名年龄相仿的正常受试者作为对照。使用递增阈值负荷试验测量功率输出。
两组患者的最大IMPO均显著降低。随着负荷增加而产生的功率输出也降低,这主要是由于吸气量(Vinsp)减少所致。试验结束时COPD患者的呼吸困难程度高于CHF患者和正常受试者。对于给定的功率水平,患者的呼吸困难程度也高于正常受试者。试验期间血氧饱和度(SpO2)无下降。
COPD和CHF患者的IMPO均同样降低。功率输出与呼吸困难的相关性比PIMax更好,可能是因为纳入了缩短速度。