Sibanda Samson, Chigwada Grace, Poole Melvin, Gwebu Ephraim T, Noletto Joseph A, Schmidt Jennifer M, Rea Angela I, Setzer William N
Department of Chemistry, University of Zimbabwe, Box MP 167, Harare, Zimbabwe.
J Ethnopharmacol. 2004 May;92(1):107-11. doi: 10.1016/j.jep.2004.02.010.
The leaf oil of Heteropyxis dehniae Suess. (Heteropyxidaceae) was obtained by hydrodistillation and analyzed by GC/MS. The most abundant essential oil components are linalool (58.3%), 4-terpineol (9.8%), alpha-terpineol (3.6%), and caryophyllene oxide (3.1%). The antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger, and the in vitro cytotoxicity of the oil on PC-3, MDA-MB-231, Hs 578T, MCF7, SK-MEL-28, and 5637 human tumor cells were also examined. Caryophyllene oxide shows notable cytotoxic activity with LC50 values of 147-351 microM.
通过水蒸馏法获得了德氏异翅香（异翅香科）的叶油，并采用气相色谱/质谱联用仪进行分析。含量最丰富的精油成分是芳樟醇（58.3%）、4-松油醇（9.8%）、α-松油醇（3.6%）和氧化石竹烯（3.1%）。还检测了该叶油对蜡样芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌、白色念珠菌和黑曲霉的抗菌活性，以及其对PC-3、MDA-MB-231、Hs 578T、MCF7、SK-MEL-28和5637人肿瘤细胞的体外细胞毒性。氧化石竹烯表现出显著的细胞毒性活性，半数致死浓度（LC50）值为147 - 351微摩尔。
