Antimicrobial Agents Unit, Faculty of science, University of Yaoundé I, P,O Box 812, Yaoundé, Cameroon.
BMC Complement Altern Med. 2014 Apr 4;14:125. doi: 10.1186/1472-6882-14-125.
Cancer has become a global public health problem and the search for new control measures is urgent. Investigation of plant products such as essential oils from Monodora myristica, Xylopia aethiopica and Xylopia parviflora might lead to new anticancer therapy. In this study, we have investigated the antineoplastic activity of essential oils from fruits of these plants growing in Chad and Cameroon.
The essential oils obtained by hydrodistillation of fruits of Monodora myristica, Xylopia aethiopica and Xylopia parviflora collected in Chad and Cameroon were analyzed by GC-FID and GC-MS and investigated for their antiproliferative activity against the breast cancer cell line (MCF7).
Overall, monoterpenes were mostly found in the six essential oils. Oils from X. aethiopica and X. parviflora from Chad and Cameroon mainly contain β-pinene at 24.6%, 28.2%, 35.7% and 32.9% respectively. Monodora myristica oils from both origins contain mainly α-phellandrene at 52.7% and 67.1% respectively. The plant origin did not significantly influence the chemical composition of oils. The six essential oils exerted cytotoxic activity against cancer (MCF-7) and normal cell lines (ARPE-19), with more pronounced effect on neoplastic cells in the majority of cases. The highest selectivity was obtained with the essential oils of X. parviflora from Chad and Cameroon (5.87 and 5.54) which were more cytotoxic against MCF-7 than against normal cell line (ARPE-19) with IC50 values of 0.155 μL/mL and 0.166 μL/mL respectively.
Essential oils from fruits of Monodora myristica, Xylopia aethiopica and Xylopia parviflora have shown acceptable antineoplastic potency, and might be investigated further in this regard.
癌症已成为全球公共卫生问题，寻找新的控制措施迫在眉睫。对植物产品（如肉豆蔻中的精油）的研究Monodora myristica、Xylopia aethiopica 和 Xylopia parviflora 可能会导致新的抗癌疗法。在这项研究中，我们研究了在乍得和喀麦隆生长的这些植物果实中的精油的抗肿瘤活性。
通过对来自乍得和喀麦隆的 Monodora myristica、Xylopia aethiopica 和 Xylopia parviflora 果实的水蒸馏获得的精油进行 GC-FID 和 GC-MS 分析，并研究其对乳腺癌细胞系（MCF7）的抗增殖活性。
总体而言，六种精油中主要发现了单萜类化合物。来自乍得和喀麦隆的 X. aethiopica 和 X. parviflora 的油主要含有β-蒎烯，分别为 24.6%、28.2%、35.7%和 32.9%。来自两个产地的 Monodora myristica 油主要含有α-松油烯，分别为 52.7%和 67.1%。植物来源并没有显著影响油的化学成分。六种精油对癌症（MCF-7）和正常细胞系（ARPE-19）均具有细胞毒性作用，在大多数情况下对肿瘤细胞的作用更为明显。来自乍得和喀麦隆的 X. parviflora 精油具有最高的选择性（5.87 和 5.54），对 MCF-7 的细胞毒性比正常细胞系（ARPE-19）更强，IC50 值分别为 0.155 μL/mL 和 0.166 μL/mL。
Monodora myristica、Xylopia aethiopica 和 Xylopia parviflora 果实中的精油表现出可接受的抗肿瘤效力，在这方面可能需要进一步研究。
