Lee Pei-Lun, Wang Jing-Houng, Tung Hung-Da, Lee Chuan-Mo, Lu Sheng-Nan
Department of Internal Medicine, Division of Hepatogastroenterology, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-pei Road, Niaosung 833 Kaohsiung, Taiwan.
Trans R Soc Trop Med Hyg. 2004 Jun;98(6):367-72. doi: 10.1016/j.trstmh.2003.10.013.
This study investigated the prevalence of antibody to hepatitis C virus (anti-HCV), evaluated clinical manifestations of hepatitis C, and explored the risk factors amongst adolescents in an HCV-hyperendemic area in Taiwan. In December 1999, 713 students aged 13-16 years from Taishi township, in central Taiwan, were enrolled in a screening program for anti-HCV and alanine transaminase (ALT) status. Fourteen participants (M/F = 6/8) were positive for anti-HCV. Eight of the 14 later proved to be negative for HCV RNA, and they demonstrated relatively low sample rate/cut-off rate (S/CO) ratios (1.05-11.83) for anti-HCV tests. All HCV RNA negative cases had normal serum ALT levels. The other six (43%) seropositive students demonstrated HCV viraemia and greater S/CO ratios (25.66-77.49). Two of these six participants had elevated serum ALT levels. Compared to anti-HCV-negative subjects, anti-HCV-positive students exhibited significantly greater rates of exposure to one or more of the following: blood transfusion, tattooing, and earlobe piercing. This study group has a greater prevalence (2%) of anti-HCV than the general Taiwanese population at the same age. The study also reveals a lower rate (43%) of chronicity of HCV infection than that reported in the literature.
本研究调查了台湾丙型肝炎病毒高流行地区青少年中丙型肝炎病毒抗体（抗-HCV）的流行情况，评估了丙型肝炎的临床表现，并探讨了危险因素。1999年12月，来自台湾中部台西乡镇的713名13至16岁学生参加了抗-HCV和丙氨酸转氨酶（ALT）状态的筛查项目。14名参与者（男/女=6/8）抗-HCV呈阳性。14名中的8名后来被证明HCV RNA为阴性，他们的抗-HCV检测样本率/临界值率（S/CO）相对较低（1.05-11.83）。所有HCV RNA阴性病例的血清ALT水平均正常。其他6名（43%）血清学阳性学生表现出HCV病毒血症且S/CO比值更高（25.66-77.49）。这6名参与者中有2名血清ALT水平升高。与抗-HCV阴性受试者相比，抗-HCV阳性学生接触以下一种或多种情况的比率显著更高：输血、纹身和穿耳洞。该研究组抗-HCV的流行率（2%）高于同年龄的台湾普通人群。该研究还显示HCV感染的慢性化率（43%）低于文献报道。
