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[儿童周围性面神经麻痹:仅在存在其他临床体征时检测莱姆病螺旋体病]

[Peripheral facial palsy in children: test for lyme borreliosis only in the presence of other clinical signs].

作者信息

Vorstman J A, Kuiper H

机构信息

Flevoziekenhuis, afd. Neurologie, Hospitaalweg 1, 1315 RA Almere.

出版信息

Ned Tijdschr Geneeskd. 2004 Apr 3;148(14):655-8.

Abstract

Peripheral facial palsy (PFP) may be the only sign of Lyme borreliosis in children. A literature study prompted by three children with PFP showed that a positive test for Borrelia burgdorferi antibodies in the blood or cerebrospinal fluid in combination with pleocytosis in the cerebrospinal fluid makes a diagnosis of Lyme borreliosis extremely probable. At least half of the children with PFP as a result of Lyme borreliosis show other signs or symptoms suggesting this disease. No data are available on the prevalence of Lyme borreliosis among children with PFP in the Netherlands; in adults, however, the prevalence is very low. Therefore, assuming a similar low prevalence in children with PFP, the predictive value of serological testing in children may be limited, in which case serological screening is not useful. Moreover, treatment with antibiotics does not seem to improve the prognosis of PFP significantly. Based on these data, serological testing and lumbar puncture is justified only in children with PFP associated with other signs or symptoms of Lyme borreliosis, such as bilaterality of the PFP, signs of meningeal irritation, a recent history of erythema migrans, arthritis or a recent tick bite.

摘要

周围性面神经麻痹(PFP)可能是儿童莱姆病的唯一症状。一项由三名患有PFP的儿童引发的文献研究表明,血液或脑脊液中伯氏疏螺旋体抗体检测呈阳性,同时脑脊液中存在细胞增多症,极有可能诊断为莱姆病。因莱姆病导致PFP的儿童中,至少有一半会出现提示该病的其他体征或症状。荷兰患有PFP的儿童中莱姆病的患病率尚无相关数据;然而,在成年人中,患病率非常低。因此,假设患有PFP的儿童患病率同样较低,血清学检测在儿童中的预测价值可能有限,在这种情况下,血清学筛查并无用处。此外,抗生素治疗似乎并不能显著改善PFP的预后。基于这些数据,仅在患有PFP且伴有莱姆病其他体征或症状的儿童中,如PFP双侧性、脑膜刺激征、近期游走性红斑病史、关节炎或近期蜱叮咬史,进行血清学检测和腰椎穿刺才是合理的。

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