Hahn Steven
Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, 1100 Fairview Ave N., A1-162, Seattle, Washington 98109, USA.
Nat Struct Mol Biol. 2004 May;11(5):394-403. doi: 10.1038/nsmb763.
Advances in structure determination of the bacterial and eukaryotic transcription machinery have led to a marked increase in the understanding of the mechanism of transcription. Models for the specific assembly of the RNA polymerase II transcription machinery at a promoter, conformational changes that occur during initiation of transcription, and the mechanism of initiation are discussed in light of recent developments.
细菌和真核生物转录机制结构测定方面的进展,使人们对转录机制的理解有了显著提高。结合近期的研究进展,本文讨论了RNA聚合酶II转录机制在启动子处的特异性组装模型、转录起始过程中发生的构象变化以及起始机制。