研究p53介导的转录激活的新时代。
A new era of studying p53-mediated transcription activation.
作者信息
Liu Wei-Li, Coleman Robert A, Singh Sameer K
机构信息
a Gruss-Lipper Biophotonics Center, Department of Anatomy and Structural Biology , Albert Einstein College of Medicine , Bronx , NY , USA.
出版信息
Transcription. 2018;9(2):102-107. doi: 10.1080/21541264.2017.1345354. Epub 2017 Oct 4.
Abstract
To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.
摘要
为了预防肿瘤发生，p53 通过促进转录机制在靶基因启动子上的募集来刺激转录。对与 p53 结合的 RNA 聚合酶 II（Pol II）进行的冷冻电子显微镜研究表明，p53 在结构上调节 Pol II 以影响其 DNA 结合和延伸，这为 p53 介导的转录调控提供了新的见解。
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