Gallimore Chris I, Lewis David, Taylor Clive, Cant Andrew, Gennery Andrew, Gray Jim J
Central Public Health Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London, UK.
J Clin Virol. 2004 Jun;30(2):196-204. doi: 10.1016/j.jcv.2003.10.007.
We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo.
我们已经证明，在一名患有软骨毛发发育不全（CHH）且存在T细胞免疫缺陷的患者接受骨髓移植（BMT）后，一种稳定的重组诺如病毒能够长期排泄。在免疫重建期间，该患者排泄一种ARG320/1999/美国样重组诺如病毒（rGII-3）达156天。在病毒排出期间，该儿童出现了症状。尚不清楚该儿童是获得了重组毒株还是体内发生了重组。
