核苷聚合酶抑制剂治疗可将小鼠粪便中诺如病毒的排出量降低至检测不到的水平，且不会出现耐药变异体。
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.
作者信息
Rocha-Pereira Joana, Van Dycke Jana, Neyts Johan
机构信息
KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium
出版信息
Antimicrob Agents Chemother. 2015 Dec 28;60(3):1907-11. doi: 10.1128/AAC.02198-15.
Abstract
Prolonged norovirus shedding may occur in certain patients, such as organ transplant recipients. We established a mouse model for persistent norovirus infection (using the mouse norovirus MNV.CR6 strain). The nucleoside viral polymerase inhibitor 2'-C-methylcytidine (2CMC), but not favipiravir (T-705), reduced viral shedding to undetectable levels. Viral rebound was observed after stopping treatment, which was again effectively controlled by treatment with 2CMC. No drug-resistant variants emerged.
摘要
在某些患者中可能会出现诺如病毒长期排毒的情况，比如器官移植受者。我们建立了一种持续性诺如病毒感染的小鼠模型（使用小鼠诺如病毒MNV.CR6毒株）。核苷类病毒聚合酶抑制剂2'-C-甲基胞苷（2CMC）可将病毒排毒量降至检测不到的水平，而法匹拉韦（T-705）则无此效果。停药后观察到病毒反弹，再次使用2CMC治疗可有效控制。未出现耐药变异株。
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