丘脑网状核在产生支持棘波和慢波的节律性丘脑-皮质活动中的作用。

Role of the thalamic reticular nucleus in the generation of rhythmic thalamo-cortical activities subserving spike and waves.

作者信息

Avanzini G, de Curtis M, Marescaux C, Panzica F, Spreafico R, Vergnes M

机构信息

Istituto Neurologico C. Besta, Milano, Italy.

出版信息

J Neural Transm Suppl. 1992;35:85-95. doi: 10.1007/978-3-7091-9206-1_6.

DOI:10.1007/978-3-7091-9206-1_6

PMID:1512596

Abstract

The role of the reticular thalamic nucleus (RTN) in pacing rhythmic cortical activities subserving spike-waves (SW) discharges has been investigated in rats. Intracellular recordings from thalamic slices in vitro demonstrated that RTN neurons from control animals possess a set of Ca2+/K+ membrane conductances which enable them to produce rhythmic oscillatory activities. In vivo, studies of Ca(2+)-conductance blockade by intrathalamic injections of Cd2+ were performed on 24 callosotomized Wistar rats displaying spontaneous SW discharges, bred at the Centre de Neurochimie, Strasbourg. A significant decrement in ipsilateral SW activity was consistently observed in all RTN-injected animals 40 min after Cd2+ injection. By contrast, animals which received Cd2+ injection into the ventroposterior complex (VP) showed only small changes in ipsilateral SW. It is concluded that Ca(2+)-dependent oscillatory properties of the RTN are critical for the expression of genetically determined SW discharges in the Wistar model.

摘要

在大鼠中，已经对丘脑网状核（RTN）在调节产生棘慢波（SW）放电的节律性皮质活动中的作用进行了研究。体外丘脑切片的细胞内记录表明，来自对照动物的RTN神经元具有一组Ca2+/K+膜电导，这使它们能够产生节律性振荡活动。在体内，对24只在斯特拉斯堡神经化学中心培育的、表现出自发性SW放电的胼胝体切开的Wistar大鼠进行了丘脑内注射Cd2+阻断Ca(2+)电导的研究。在注射Cd2+后40分钟，在所有注射RTN的动物中均持续观察到同侧SW活动显著减少。相比之下，将Cd2+注射到腹后复合体（VP）的动物同侧SW仅有微小变化。得出的结论是，RTN的Ca(2+)依赖性振荡特性对于Wistar模型中基因决定的SW放电的表达至关重要。