Durazo Francisco A, Lassman Charles, Han Steven H B, Saab Sammy, Lee Nancy P, Kawano Marvin, Saggi Bob, Gordon Sherilyn, Farmer Douglas G, Yersiz Hasan, Goldstein R Leonard I, Ghobrial Mark, Busuttil Ronald W
Division of Digestive Diseases, Department of Medicin,; Dumont-UCLA Liver Transplant Center, University of California, Los Angeles, California 90095-9302, USA.
Am J Gastroenterol. 2004 May;99(5):950-2. doi: 10.1111/j.1572-0241.2004.04165.x.
The use of complementary and alternative medicine (CAM) in developed countries has increased significantly over the years. Among the most popular are the weight loss supplements or "fat burners." Liver failure due to these popular remedies has been widely recognized. Usnic acid has been an ingredient of dietary supplements that cause liver failure. Its hepatotoxicity has not been recognized because it is usually mixed with other ingredients that are presumably hepatotoxic. We describe a case of a 28-yr-old woman who presented with fulminant liver failure requiring orthotopic liver transplantation, after taking pure usnic acid for weight loss. This is the first report on fulminant liver failure associated with the ingestion of pure usnic acid. A discussion about hepatotoxicity of the different compounds of dietary supplements is presented. This is a reminder for the clinicians about the potential side effects of CAM.
近年来，发达国家中补充和替代医学（CAM）的使用显著增加。其中最受欢迎的是减肥补充剂或“脂肪燃烧剂”。因这些流行疗法导致的肝衰竭已得到广泛认可。松萝酸一直是导致肝衰竭的膳食补充剂的一种成分。其肝毒性尚未被认识到，因为它通常与其他据推测具有肝毒性的成分混合在一起。我们描述了一例28岁女性病例，该患者在服用纯松萝酸减肥后出现暴发性肝衰竭，需要进行原位肝移植。这是关于摄入纯松萝酸导致暴发性肝衰竭的首例报告。本文还对膳食补充剂中不同化合物的肝毒性进行了讨论。这提醒临床医生注意补充和替代医学的潜在副作用。
