Sanchez William, Maple John T, Burgart Lawrence J, Kamath Patrick S
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Mayo Clin Proc. 2006 Apr;81(4):541-4. doi: 10.4065/81.4.541.
Dietary supplements containing usnic acid are marketed for weight loss and have been associated with hepatotoxicity. The specific ingredient responsible for the hepatotoxicity is currently unknown. We describe 2 patients who developed severe hepatotoxicity within 3 months of taking a dietary supplement containing usnic acid. One patient developed fulminant hepatic failure requiring emergency liver transplantation; the other developed submassive hepatic necrosis but did not require transplantation. Thorough investigation, including histopathological examination of the liver, revealed no other cause of acute liver injury. Usnic acid hepatotoxicity should be considered as a possible etiologic factor in patients presenting with fulminant hepatic failure, especially if they have been taking dietary supplements for weight reduction.
含有松萝酸的膳食补充剂被用于减肥，且已被发现与肝毒性有关。目前尚不清楚导致肝毒性的具体成分。我们描述了2例在服用含松萝酸的膳食补充剂3个月内出现严重肝毒性的患者。其中1例患者发生暴发性肝衰竭，需要紧急进行肝移植；另1例发生亚大块肝坏死，但不需要移植。经过全面调查，包括肝脏组织病理学检查，未发现其他急性肝损伤原因。对于出现暴发性肝衰竭的患者，尤其是那些一直在服用减肥膳食补充剂的患者，应考虑松萝酸肝毒性是可能的病因。
