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危险的膳食补充剂:与肝衰竭相关且需要进行肝移植。

Dangerous dietary supplements: -associated hepatic failure requiring transplantation.

作者信息

Lunsford Keri E, Bodzin Adam S, Reino Diego C, Wang Hanlin L, Busuttil Ronald W

机构信息

Keri E Lunsford, Adam S Bodzin, Diego C Reino, Ronald W Busuttil, The Pfleger Liver Institute, The Dumont-UCLA Liver Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, United States.

出版信息

World J Gastroenterol. 2016 Dec 7;22(45):10071-10076. doi: 10.3748/wjg.v22.i45.10071.

Abstract

Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. extract and containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients.

摘要

商业膳食补充剂被宣传为病态肥胖者寻求可持续减肥的万灵药。不幸的是,许多补充剂所宣称的功效并无依据且监管不足。然而,最令人担忧的是其相关的有害副作用,而消费者往往并未意识到这些。含有[提取物名称]提取物的产品是目前市场上最受欢迎的一些减肥膳食补充剂。在此,我们报告首例与这种膳食补充剂相关的暴发性肝衰竭病例。这种补充剂中的一种活性成分是羟基柠檬酸,2009年因具有肝毒性而被美国食品药品监督管理局禁止的减肥补充剂中也含有这种活性成分。必须提高对诸如[补充剂名称]等膳食补充剂危险性的认识,以防止更多患者出现肝毒性和潜在的暴发性肝衰竭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdaf/5143754/d3b197a266e5/WJG-22-10071-g001.jpg

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