Casolari Jason M, Silver Pamela A
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Trends Cell Biol. 2004 May;14(5):222-5. doi: 10.1016/j.tcb.2004.03.007.
The production of a mature mRNA requires the assembly and cooperation of numerous complexes before nuclear export. The deleterious effects of intron-containing pre-mRNA leakage into the cytoplasm necessitate mechanisms to prevent premature export of partially processed or unprocessed messages. A new study demonstrates that the Saccharomyces cerevisiae protein Mlp1 specifically retains intron-containing pre-mRNAs in the nucleus.
成熟mRNA的产生需要在核输出之前众多复合物的组装与协作。含内含子的前体mRNA泄漏到细胞质中会产生有害影响，因此需要机制来防止部分加工或未加工的信息过早输出。一项新研究表明，酿酒酵母蛋白Mlp1能特异性地将含内含子的前体mRNA保留在细胞核中。
