Harma Muge, Harma Mehmet, Kocyigit Abdurrahim, Yurtseven Seniz, Demir Nurettin
Department of Gynecology and Obstetrics, Faculty of Medicine, University of Harran, Sanliurfa, Turkey.
J Reprod Med. 2004 Apr;49(4):285-8.
To investigate the association, if any, between serum concentrations of folate, vitamin B12 and homocysteine in complete hydatiform mole (CHM).
Blood samples were taken from 37 women with CHM and 52 healthy controls in the first trimester of pregnancy. Serum was analyzed for folate, vitamin B12 and homocysteine using electrochemiluminescence and chemiluminescence assay.
In patients with CHM, significantly higher mean levels of serum vitamin B12 were encountered (247.21 versus 180.32 pg/mL, P=.012). Significantly lower mean levels of serum folate were found in patients with CHM as compared with controls (7.91 versus 10.72 ng/mL, P=.008). Homocysteine levels tended to be higher in patients with CHM, but the difference was not statistically significant (10.58 versus 8.79 nmol/mL, P=.104).
This is the first report to suggest an association between folate, vitamin B12 and CHM. Folate may play a protective role in preventing CHM.
探讨完全性葡萄胎（CHM）患者血清叶酸、维生素B12和同型半胱氨酸浓度之间是否存在关联（若有）。
在妊娠早期采集37例CHM患者和52例健康对照者的血样。采用电化学发光和化学发光分析法分析血清中的叶酸、维生素B12和同型半胱氨酸。
CHM患者血清维生素B12平均水平显著更高（247.21对180.32 pg/mL，P = 0.012）。与对照组相比，CHM患者血清叶酸平均水平显著更低（7.91对10.72 ng/mL，P = 0.008）。CHM患者同型半胱氨酸水平倾向于更高，但差异无统计学意义（10.58对8.79 nmol/mL，P = 0.104）。
这是首份提示叶酸、维生素B12与CHM之间存在关联的报告。叶酸可能在预防CHM中发挥保护作用。
