Khuwaja A K, Rafique G, White F, Azam S I
Department of Community Health Sciences, The Aga Khan University, Karachi.
J Pak Med Assoc. 2004 Feb;54(2):60-6.
To assess the prevalence of macrovascular complications and factors associated with these complications among persons with Type 2 diabetes.
A multi-center, cross-sectional survey was conducted in three diabetes clinics of Karachi from November 2000 to April 2001. Six hundred and seventy-two persons were interviewed to determine the prevalence of ischemic heart disease (IHD), cerebrovascular disease (CVA) and diabetic foot (DF). Demographic data and co-variables obtained include age, sex, duration of diabetes, body mass index (BMI), smoking status, exercise habits and history of hypertension (HTN).
Overall, 26.4%, 6.8% and 3.9% of individuals had IHD, CVA and DF respectively. Multiple logistic regression analysis showed that subjects having IHD were more likely to have HTN (AOR=1.88, 95% CI 1.31-2.69), not performing regular exercise (AOR = 2.09, 95% CI 1.39-3.17) and be current smokers (AOR = 1.85, 95% CI 1.10-3.10) Subjects having CVA were more likely to have diabetes for more than 5 years (AOR = 1.94, 95% CI 0.97-3.87). Males were more prone than females to have DF (AOR = 3.48, 95% CI 1.46-8.31). Those who had DF were more likely to have diabetes for more than 5 years (AOR = 3.29, 95% CI 1.09-9.89) and of reporting current smoking (AOR = 4.01, 95% CI 1.49-10.71).
Large proportions of persons with Type 2 diabetes were suffering from preventable macrovascular complications in Karachi, Pakistan. There is a need to develop risk factor modification interventions to reduce the impact of long-term complications.
评估2型糖尿病患者大血管并发症的患病率以及与这些并发症相关的因素。
2000年11月至2001年4月在卡拉奇的三家糖尿病诊所进行了一项多中心横断面调查。对672人进行了访谈，以确定缺血性心脏病（IHD）、脑血管疾病（CVA）和糖尿病足（DF）的患病率。获得的人口统计学数据和协变量包括年龄、性别、糖尿病病程、体重指数（BMI）、吸烟状况、运动习惯和高血压（HTN）病史。
总体而言，分别有26.4%、6.8%和3.9%的个体患有IHD、CVA和DF。多因素logistic回归分析显示，患有IHD的受试者更有可能患有HTN（比值比[AOR]=1.88，95%置信区间[CI]1.31-2.69）、不经常锻炼（AOR=2.09，95%CI 1.39-3.17）以及当前吸烟（AOR=1.85，95%CI 1.10-3.10）。患有CVA的受试者更有可能患糖尿病超过5年（AOR=1.94，95%CI 0.97-3.87）。男性比女性更容易患DF（AOR=3.48，95%CI 1.46-8.31）。患有DF的人更有可能患糖尿病超过5年（AOR=3.29，95%CI 1.09-9.89）以及报告当前吸烟（AOR=4.01，95%CI 1.49-10.71）。
在巴基斯坦卡拉奇，很大比例的2型糖尿病患者患有可预防的大血管并发症。有必要制定危险因素修正干预措施，以减少长期并发症的影响。
