Wortmann Robert L
Department of Internal Medicine, The University of Oklahoma College of Medicine, 4502 East 41st Street, Tulsa, OK 74137, USA.
Curr Rheumatol Rep. 2004 Jun;6(3):235-9. doi: 10.1007/s11926-004-0074-4.
An attack of acute gouty arthritis is one the most painful episodes that can be experienced by humans. Fortunately, there are three classes of agents that can effectively terminate the acute attack. These include colchicine, nonsteroidal anti-inflammatory drugs, and glucocorticoids. If therapy with any one of these is initiated promptly after the onset of symptoms, relief should occur quickly. Recent observations have increased the knowledge of crystal-induced acute inflammatory responses. These observations allow a better understanding of the mechanisms of action of these agents and provide the rationale for using them in combination in severe or refractory cases.
急性痛风性关节炎发作是人类所能经历的最痛苦的病症之一。幸运的是，有三类药物可以有效终止急性发作。这些药物包括秋水仙碱、非甾体抗炎药和糖皮质激素。如果在症状出现后迅速开始使用其中任何一种进行治疗，疼痛应会很快缓解。最近的观察增加了对晶体诱导的急性炎症反应的了解。这些观察有助于更好地理解这些药物的作用机制，并为在严重或难治性病例中联合使用它们提供了理论依据。
