Borzacchiello G, Paciello O, Papparella S
Universita degli Studi di Napoli Federico II, Dipartimento di Patologia e Sanita Animale, Via F. Delpino, 1, Napoli 80137, Italy.
J Comp Pathol. 2004 Jul;131(1):70-6. doi: 10.1016/j.jcpa.2004.01.006.
Cyclooxygenase-1 (COX-1) and cyclooxygenase -2 (COX-2) are known to play a role in the carcinogenesis of many human and animal primary epithelial tumours. However, expression of COX-1 and -2 has not been investigated in canine nasal epithelial carcinoma, a rare form of neoplasia. COX-1 immunolabelling was demonstrated in normal canine nasal mucosa and in a minority of neoplastic specimens. Cytoplasmic COX-2, however, was strongly expressed in the majority of canine nasal carcinomas. In addition, COX-2 expression was demonstrated in dysplastic epithelium and in a proportion of stromal cells. Co-expression of both enzyme isoforms was revealed by confocal laser scanning microscopy. The results indicate that COX-2 is overexpressed in a proportion of naturally occurring canine nasal carcinomas, suggesting its possible role in canine nasal tumorigenesis.
已知环氧化酶-1（COX-1）和环氧化酶-2（COX-2）在许多人类和动物原发性上皮肿瘤的致癌过程中发挥作用。然而，尚未对犬鼻上皮癌（一种罕见的肿瘤形式）中COX-1和COX-2的表达进行研究。在正常犬鼻黏膜和少数肿瘤标本中证实了COX-1免疫标记。然而，细胞质COX-2在大多数犬鼻癌中强烈表达。此外，在发育异常的上皮和一定比例的基质细胞中也证实了COX-2的表达。共聚焦激光扫描显微镜显示两种酶同工型共表达。结果表明，COX-2在一部分自然发生的犬鼻癌中过度表达，提示其在犬鼻肿瘤发生中可能发挥的作用。
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