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脑瘫

Cerebral palsy.

作者信息

Koman L Andrew, Smith Beth Paterson, Shilt Jeffrey S

机构信息

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1070, USA.

出版信息

Lancet. 2004 May 15;363(9421):1619-31. doi: 10.1016/S0140-6736(04)16207-7.

Abstract

Cerebral palsy, a range of non-progressive syndromes of posture and motor impairment, is a common cause of disability in childhood. The disorder results from various insults to different areas within the developing nervous system, which partly explains the variability of clinical findings. Management options include physiotherapy, occupational and speech therapy, orthotics, device-assisted modalities, pharmacological intervention, and orthopaedic and neurosurgical procedures. Since 1980, modification of spasticity by means of orally administered drugs, intramuscular chemodenervation agents (alcohol, phenol, botulinum toxin A), intrathecally administered drugs (baclofen), and surgery (neurectomy, rhizotomy) has become more frequent. Family-directed use of holistic approaches for their children with cerebral palsy includes the widespread adoption of complementary and alternative therapies; however, the prevalence of their use and the cost of these options are unknown. Traditional medical techniques (physiotherapy, bracing, and orthopaedic musculoskeletal surgery) remain the mainstay of treatment strategies at this time. This seminar addresses only the musculoskeletal issues associated with cerebral palsy and only indirectly discusses the cognitive, medical, and social issues associated with this diagnosis.

摘要

脑瘫是一系列非进行性的姿势和运动障碍综合征,是儿童残疾的常见原因。该病症由发育中的神经系统内不同区域受到的各种损伤引起,这在一定程度上解释了临床症状的变异性。治疗选择包括物理治疗、职业和言语治疗、矫形器、器械辅助治疗、药物干预以及骨科和神经外科手术。自1980年以来,通过口服药物、肌肉化学去神经药物(酒精、苯酚、肉毒杆菌毒素A)、鞘内给药(巴氯芬)以及手术(神经切除术、神经根切断术)来改善痉挛的情况变得更加常见。以家庭为导向的针对脑瘫患儿的整体治疗方法包括广泛采用补充和替代疗法;然而,这些疗法的使用 prevalence 以及这些选择的成本尚不清楚。传统医学技术(物理治疗、支具和骨科肌肉骨骼手术)目前仍然是治疗策略的 mainstay。本次研讨会仅讨论与脑瘫相关的肌肉骨骼问题,仅间接讨论与该诊断相关的认知、医学和社会问题。 (注:原文中“prevalence”未翻译,“mainstay”未准确翻译,可能是输入有误,可根据正确内容进行调整)

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