[Study of biosynthesis of mycoheptin, mycopentene and fatty acids by Streptoverticillium mycoheptinicum strain 255 in various conditions of its cultivation].

The effect of the fat content in the medium for cultivation of Streptoverticillium mycoheptinium-255 and the effect of glucose intake on the rate of carbohydrate utilization and intensity of incorporation of labeled sodium acetate and propionate to mycoheptin, mycopentene and fatty acids were studied. It was shown that a lower fat content in the medium in comparison with the optimal one resulted in intensification carbohydrate catabolism during an idiophase, increased production rates of mycopentene, an accompanying antibiotic, and fatty acids and a decrease in the heptaene/pentaene ratio. The optimal contents of the oil in the medium provided a decrease in the rate of the carbohydrate consumption and preferable production of the required antibiotic or mycoheptin accompanied by a decrease in the synthesis rate of mycopentene and fatty acids.