Shay Jerry W, Wright Woodring E
University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Mol Cell. 2004 May 21;14(4):420-1. doi: 10.1016/s1097-2765(04)00269-2.
A network of ATM/ATR-mediated events regulates cell cycle checkpoints and genomic integrity and contributes to the processing of DNA double-strand breaks in both genomic DNA and at telomeres. In yeast and in human cells, investigators, including, and Herbig et al., published in this issue of Molecular Cell, are beginning to decipher the signaling pathways involved at the telomeres.
由ATM/ATR介导的一系列事件构成的网络调节细胞周期检查点和基因组完整性，并有助于处理基因组DNA和端粒处的DNA双链断裂。在酵母和人类细胞中，包括本期《分子细胞》上发表论文的作者赫比格等人在内的研究人员，正开始破解端粒处涉及的信号通路。
